Cannabidiol (CBD) obtained from hemp and cannabis plants has therapeutic and medical effects that make it useful for the treatment of a number of ailments. It is very effective for reducing pain, inflammation, anxiety, stress, and other such symptoms of diseases. This is due to CBD enhancing the endocannabinoid system (ECS) which improves the immune system, cardiovascular system and neurological functioning. Because of this, we can use CBD oil for seizures due to epilepsy, and clinical studies have shown it to be effective. In this article, we will attempt to answer some doubts regarding the use of CBD for treating epilepsy.
The FDA Guidelines About The Use Of CBD For Epilepsy
According to the FDA, CBD products like oils are not approved for the mitigation, cure, treatment or prevention of any diseases. However, it has approved the use of the drug Epidiolex which is made from synthetic CBD for the treatment of Lennox-Gastaut syndrome and Dravet syndrome in children above the age of two. These are rare and severe forms of drug-resistant types of epilepsy.
The Use Of CBD For Epilepsy According To Current Research
The results from scientific studies and minor clinical studies have shown that CBD is effective in reducing the severity and frequency of seizures. This is due to its anticonvulsant effects because of how it interacts with the neurotransmitters in the brain. This is especially true when it comes to treating Lennox-Gastaut syndrome and Dravet syndrome in children, as well as in adults. The anticonvulsant effect is because CBD reduces the excessive firing of neurons due to overstimulation; in short, it acts like circuit breakers. This is also the reason it is useful in treating symptoms due to neurodegenerative diseases.
CBD Dosage For Epilepsy
Just like finding cannabidiol (CBD) dosage for other ailments, you will have to find the minimum effective dosage and this can vary from person to person. This is done by using a stepwise dosing method. In this, you find a baseline dosage and incrementally adjust the dose over a fixed period of time until you arrive at the effective dose.
Stepwise Dosing Of CBD For Epilepsy
It is always recommended to begin at a low dose as the baseline dosage which is usually between 2 to 5mg of CBD two or three times daily, listed below are the steps to do stepwise dosing.
- Maintain the baseline dosage for 7 days and while administering this dose make a journal entry on how CBD interacts with your body.
- Increase the dosage after the initial 7 days, if you are not experiencing the benefits from the baseline dosage. Increase it at the rate of 1 to 2mg every three days until you arrive at the optimal dose that works best.
- Now that you have found the minimum effective dosage, try reducing the dose to see whether you can maintain the benefits.
Also keep in mind that as you consume CBD, the endocannabinoid system (ECS) gets habituated to it and because of this you might get the same effects at a lower dose. You will also experience other health benefits because it works on the whole body and you must keep a note of this when consuming it for the first time. Besides, people suffering from epilepsy also suffer from sleep disorders due to the seizures and CBD might help with providing sound sleep. So, this must also be taken into consideration when determining the minimum effective dosage.
CBD Oil Baseline Dosage Based On Weight
|Condition||Weight 31 to 60 lbs||Weight 61 to 100 lbs||Weight 100 to 175 lbs||Weight 175 to 250 lbs|
|2mg to 4mg||4mg to 6mg||6mg to 8mg||8mg to 10mg|
|2||4mg to 8mg||6mg to 12mg||8mg to 18mg||12mg to 20mg|
|8mg to 12mg||12mg to18mg||18mg to 24 mg||22mg to 30mg|
|4||12mg to 18mg||18mg to 24mg||24mg to 32mg||32mg to 40mg|
|18mg to 30mg||24mg to 40mg||32mg to 60mg||42mg to 60mg|
Side Effects Of CBD Oil
There are minor side effects of CBD oil consumption and only some people experience it. At the same time, some experience it the first time they consume CBD and the effects disappear on subsequent usage. But, the severity of these side effects will be high on overdosing and the symptoms are listed below.
Inhibition Of CYP450 Liver Enzyme: It is understood from research that CBD has the effect of reducing or inhibiting the effectiveness of the liver enzyme CYP450, this enzyme is responsible for the metabolism of pharmaceutical drugs. So, CBD reduces the metabolic capacity of the liver and you must be aware of that if you are consuming any type of antiepileptic drug.
Dry Mouth: CBD imparts its effects by influencing the endocannabinoid system (ECS) and this system has its receptors in the oral cavity. So, consuming CBD oil causes the salivary glands to secrete less saliva and results in dry mouth.
Drowsiness: CBD causes calmness and relaxation, but at higher doses, this may cause drowsiness, and one of the best ways to avoid this is by microdosing CBD oil.
These are some of the points that you should keep in mind before using CBD oil for treating epilepsy.